Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FGD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:14,532,598–14,533,121 | 278.0 kb | Distal (>10kb) Multiome | 210 | |
| chr3:14,601,718–14,603,350 | 207.8 kb | Distal (>10kb) Multiome | 282 | |
| chr3:14,651,173–14,652,219 | 159.2 kb | Distal (>10kb) Multiome | 942 | |
| chr3:14,809,795–14,809,942 | 909 bp | At TSS | 15 | |
| chr3:14,810,059–14,811,386 | 234 bp | At TSS Multiome | 162 | |
| chr3:14,847,690–14,848,492 | 37.3 kb | Distal (>10kb) Multiome | 317 | |
| chr3:14,947,039–14,949,016 | 137.6 kb | Distal (>10kb) Multiome | 992 | |
| chr3:15,064,860–15,065,480 | 254.5 kb | Distal (>10kb) Multiome | 832 | |
| chr3:15,098,771–15,099,764 | 288.3 kb | Distal (>10kb) Multiome | 1059 |
Genomic view of the FGD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.