This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for FEM1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FEM1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FEM1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:68,053,850–68,055,256 | 223.4 kb | Distal (>10kb) Multiome | 832 | |
| chr15:68,229,045–68,230,269 | 48.0 kb | Distal (>10kb) Multiome | 889 | |
| chr15:68,256,694–68,257,399 | 20.6 kb | Distal (>10kb) Multiome | 551 | |
| chr15:68,277,201–68,278,718 | 176 bp | At TSS Multiome | 1100 | |
| chr15:68,431,141–68,432,391 | 154.4 kb | Distal (>10kb) Multiome | 295 | |
| chr15:68,542,811–68,543,454 | 265.3 kb | Distal (>10kb) Multiome | 155 | |
| chr15:68,559,409–68,560,165 | 282.0 kb | Distal (>10kb) Multiome | 531 |
Genomic view of the FEM1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.