This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for FDPS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FDPS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FDPS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:155,017,084–155,017,941 | 291.3 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:155,050,292–155,052,078 | 257.6 kb | Distal (>10kb) Multiome | 948 | |
| chr1:155,061,415–155,064,552 | 244.9 kb | Distal (>10kb) Multiome | 860 | |
| chr1:155,070,748–155,071,423 | 237.7 kb | Distal (>10kb) Multiome | 542 | |
| chr1:155,078,524–155,079,535 | 230.0 kb | Distal (>10kb) Multiome | 397 | |
| chr1:155,079,852–155,081,529 | 227.9 kb | Distal (>10kb) Multiome | 539 | |
| chr1:155,084,373–155,086,501 | 223.8 kb | Distal (>10kb) Multiome | 865 | |
| chr1:155,091,315–155,091,900 | 217.3 kb | Distal (>10kb) Multiome | 594 | |
| chr1:155,126,247–155,126,903 | 182.4 kb | Distal (>10kb) Multiome | 776 | |
| chr1:155,127,607–155,128,120 | 181.0 kb | Distal (>10kb) Multiome | 578 | |
| chr1:155,135,100–155,136,750 | 173.0 kb | Distal (>10kb) Multiome | 938 | |
| chr1:155,166,847–155,168,170 | 141.0 kb | Distal (>10kb) Multiome | 622 | |
| chr1:155,172,629–155,174,979 | 135.6 kb | Distal (>10kb) Multiome | 903 | |
| chr1:155,192,921–155,194,099 | 115.3 kb | Distal (>10kb) Multiome | 755 | |
| chr1:155,194,230–155,195,403 | 114.0 kb | Distal (>10kb) Multiome | 753 | |
| chr1:155,196,127–155,196,592 | 112.5 kb | Distal (>10kb) Multiome | 97 | |
| chr1:155,207,822–155,209,789 | 99.9 kb | Distal (>10kb) Multiome | 826 | |
| chr1:155,226,522–155,227,197 | 82.3 kb | Distal (>10kb) Multiome | 600 | |
| chr1:155,227,312–155,228,116 | 81.2 kb | Distal (>10kb) Multiome | 688 | |
| chr1:155,244,103–155,245,349 | 64.1 kb | Distal (>10kb) Multiome | 900 | |
| chr1:155,250,356–155,251,199 | 58.0 kb | Distal (>10kb) Multiome | 605 | |
| chr1:155,255,032–155,255,921 | 53.3 kb | Distal (>10kb) Multiome | 661 | |
| chr1:155,261,679–155,262,788 | 46.5 kb | Distal (>10kb) Multiome | 921 | |
| chr1:155,272,928–155,274,098 | 35.3 kb | Distal (>10kb) Multiome | 768 | |
| chr1:155,276,933–155,278,884 | 30.3 kb | Distal (>10kb) Multiome | 749 | |
| chr1:155,307,428–155,307,646 | 1.2 kb | Proximal (<10kb) | 307 | |
| chr1:155,308,291–155,309,348 | 121 bp | At TSS Multiome | 934 | |
| chr1:155,320,564–155,321,470 | 12.0 kb | Distal (>10kb) Multiome | 341 | |
| chr1:155,322,680–155,325,643 | 15.5 kb | Distal (>10kb) Multiome | 979 | |
| chr1:155,562,014–155,563,482 | 254.1 kb | Distal (>10kb) Multiome | 909 |
Genomic view of the FDPS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.