This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FDFT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FDFT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FDFT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:11,563,746–11,564,943 | 238.0 kb | Distal (>10kb) Multiome | 644 | |
| chr8:11,617,248–11,618,158 | 184.9 kb | Distal (>10kb) Multiome | 126 | |
| chr8:11,632,784–11,633,414 | 169.6 kb | Distal (>10kb) Multiome | 233 | |
| chr8:11,642,077–11,643,101 | 160.1 kb | Distal (>10kb) Multiome | 247 | |
| chr8:11,660,832–11,661,535 | 141.5 kb | Distal (>10kb) Multiome | 21 | |
| chr8:11,682,733–11,683,887 | 119.6 kb | Distal (>10kb) Multiome | 157 | |
| chr8:11,702,714–11,704,461 | 99.6 kb | Distal (>10kb) Multiome | 687 | |
| chr8:11,708,271–11,710,646 | 92.6 kb | Distal (>10kb) Multiome | 246 | |
| chr8:11,736,329–11,736,895 | 66.2 kb | Distal (>10kb) Multiome | 615 | |
| chr8:11,743,316–11,744,611 | 58.5 kb | Distal (>10kb) Multiome | 243 | |
| chr8:11,769,172–11,770,442 | 33.0 kb | Distal (>10kb) Multiome | 764 | |
| chr8:11,801,766–11,803,423 | 153 bp | At TSS Multiome | 901 | |
| chr8:11,805,652–11,806,315 | 2.9 kb | Proximal (<10kb) | 92 | |
| chr8:11,807,986–11,809,046 | 5.7 kb | Proximal (<10kb) Multiome | 514 | |
| chr8:11,867,298–11,868,997 | 65.4 kb | Distal (>10kb) Multiome | 752 | |
| chr8:11,902,256–11,902,767 | 99.7 kb | Distal (>10kb) Multiome | 604 | |
| chr8:11,986,166–11,987,022 | 183.9 kb | Distal (>10kb) Multiome | 233 |
Genomic view of the FDFT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.