Enables identical protein binding activity. Involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FCHO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FCHO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FCHO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:72,816,070–72,817,456 | 139.4 kb | Distal (>10kb) Multiome | 858 | |
| chr5:72,847,979–72,849,263 | 107.8 kb | Distal (>10kb) Multiome | 947 | |
| chr5:72,955,335–72,956,832 | 68 bp | At TSS Multiome | 941 | |
| chr5:73,119,738–73,120,989 | 164.5 kb | Distal (>10kb) Multiome | 332 | |
| chr5:73,201,724–73,202,388 | 246.0 kb | Distal (>10kb) Multiome | 402 | |
| chr5:73,215,701–73,216,633 | 260.2 kb | Distal (>10kb) Multiome HiCAR | 817 |
Genomic view of the FCHO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.