FCGRT
Fc gamma receptor and transporter | FcRn, FcgammaRn

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Developmental clusters: GC7
Biological processes 11 terms
Expression (TPM)
FCGRT — as a Regulated Gene

TFs regulating FCGRT 0 TFs

Transcription factors with Perturb-seq knockdown data for FCGRT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FCGRT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to FCGRT

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FCGRT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:49,210,032–49,211,225 301.8 kb Distal (>10kb) Multiome 366
chr19:49,337,997–49,340,482 173.2 kb Distal (>10kb) Multiome 612
chr19:49,361,283–49,362,837 150.8 kb Distal (>10kb) Multiome 553
chr19:49,362,970–49,364,306 148.7 kb Distal (>10kb) Multiome 616
chr19:49,403,611–49,404,247 108.4 kb Distal (>10kb) Multiome 305
chr19:49,432,343–49,432,785 79.8 kb Distal (>10kb) Multiome 103
chr19:49,436,149–49,436,821 75.9 kb Distal (>10kb) Multiome 248
chr19:49,441,067–49,441,861 70.9 kb Distal (>10kb) Multiome 223
chr19:49,442,072–49,444,054 69.4 kb Distal (>10kb) Multiome 914
chr19:49,451,347–49,452,239 60.5 kb Distal (>10kb) Multiome 764
chr19:49,452,723–49,453,850 59.0 kb Distal (>10kb) Multiome 847
chr19:49,476,063–49,476,551 36.0 kb Distal (>10kb) Multiome 244
chr19:49,487,027–49,488,279 24.9 kb Distal (>10kb) Multiome 964
chr19:49,495,613–49,496,661 16.2 kb Distal (>10kb) Multiome 919
chr19:49,497,318–49,497,509 9.3 kb Proximal (<10kb) 277
chr19:49,500,403–49,501,353 11.7 kb Distal (>10kb) Multiome 405
chr19:49,506,679–49,506,892 at TSS At TSS 375
chr19:49,512,565–49,513,700 705 bp At TSS Multiome 655
chr19:49,527,651–49,528,221 15.6 kb Distal (>10kb) Multiome 354
chr19:49,533,232–49,534,476 21.7 kb Distal (>10kb) Multiome 534
chr19:49,555,629–49,557,180 43.8 kb Distal (>10kb) Multiome HiCAR 294
chr19:49,580,125–49,580,813 68.2 kb Distal (>10kb) Multiome 848
chr19:49,589,601–49,594,008 81.2 kb Distal (>10kb) Multiome 994
chr19:49,638,063–49,638,728 125.9 kb Distal (>10kb) Multiome 237
chr19:49,639,671–49,642,787 128.0 kb Distal (>10kb) Multiome 1067
chr19:49,664,165–49,665,096 152.2 kb Distal (>10kb) Multiome 679
chr19:49,665,345–49,666,430 153.5 kb Distal (>10kb) Multiome 721
chr19:49,672,105–49,672,787 160.0 kb Distal (>10kb) Multiome HiCAR 625
chr19:49,676,058–49,678,754 164.6 kb Distal (>10kb) Multiome HiCAR 1033
chr19:49,680,433–49,681,147 168.4 kb Distal (>10kb) Multiome 435
chr19:49,690,485–49,691,761 178.7 kb Distal (>10kb) Multiome 327
chr19:49,746,188–49,746,748 234.1 kb Distal (>10kb) Multiome 283
chr19:49,766,231–49,767,440 254.3 kb Distal (>10kb) Multiome 718
chr19:49,802,146–49,802,787 290.1 kb Distal (>10kb) Multiome 200
chr19:49,805,226–49,805,871 293.2 kb Distal (>10kb) Multiome 245
chr19:49,808,201–49,809,746 296.6 kb Distal (>10kb) Multiome 509
chr19:49,812,926–49,813,834 301.1 kb Distal (>10kb) Multiome 650

Genome Browser

Genomic view of the FCGRT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:49,200,032 – 49,823,834
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq