This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Transcription factors with Perturb-seq knockdown data for FCGRT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FCGRT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FCGRT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,210,032–49,211,225 | 301.8 kb | Distal (>10kb) Multiome | 366 | |
| chr19:49,337,997–49,340,482 | 173.2 kb | Distal (>10kb) Multiome | 612 | |
| chr19:49,361,283–49,362,837 | 150.8 kb | Distal (>10kb) Multiome | 553 | |
| chr19:49,362,970–49,364,306 | 148.7 kb | Distal (>10kb) Multiome | 616 | |
| chr19:49,403,611–49,404,247 | 108.4 kb | Distal (>10kb) Multiome | 305 | |
| chr19:49,432,343–49,432,785 | 79.8 kb | Distal (>10kb) Multiome | 103 | |
| chr19:49,436,149–49,436,821 | 75.9 kb | Distal (>10kb) Multiome | 248 | |
| chr19:49,441,067–49,441,861 | 70.9 kb | Distal (>10kb) Multiome | 223 | |
| chr19:49,442,072–49,444,054 | 69.4 kb | Distal (>10kb) Multiome | 914 | |
| chr19:49,451,347–49,452,239 | 60.5 kb | Distal (>10kb) Multiome | 764 | |
| chr19:49,452,723–49,453,850 | 59.0 kb | Distal (>10kb) Multiome | 847 | |
| chr19:49,476,063–49,476,551 | 36.0 kb | Distal (>10kb) Multiome | 244 | |
| chr19:49,487,027–49,488,279 | 24.9 kb | Distal (>10kb) Multiome | 964 | |
| chr19:49,495,613–49,496,661 | 16.2 kb | Distal (>10kb) Multiome | 919 | |
| chr19:49,497,318–49,497,509 | 9.3 kb | Proximal (<10kb) | 277 | |
| chr19:49,500,403–49,501,353 | 11.7 kb | Distal (>10kb) Multiome | 405 | |
| chr19:49,506,679–49,506,892 | at TSS | At TSS | 375 | |
| chr19:49,512,565–49,513,700 | 705 bp | At TSS Multiome | 655 | |
| chr19:49,527,651–49,528,221 | 15.6 kb | Distal (>10kb) Multiome | 354 | |
| chr19:49,533,232–49,534,476 | 21.7 kb | Distal (>10kb) Multiome | 534 | |
| chr19:49,555,629–49,557,180 | 43.8 kb | Distal (>10kb) Multiome HiCAR | 294 | |
| chr19:49,580,125–49,580,813 | 68.2 kb | Distal (>10kb) Multiome | 848 | |
| chr19:49,589,601–49,594,008 | 81.2 kb | Distal (>10kb) Multiome | 994 | |
| chr19:49,638,063–49,638,728 | 125.9 kb | Distal (>10kb) Multiome | 237 | |
| chr19:49,639,671–49,642,787 | 128.0 kb | Distal (>10kb) Multiome | 1067 | |
| chr19:49,664,165–49,665,096 | 152.2 kb | Distal (>10kb) Multiome | 679 | |
| chr19:49,665,345–49,666,430 | 153.5 kb | Distal (>10kb) Multiome | 721 | |
| chr19:49,672,105–49,672,787 | 160.0 kb | Distal (>10kb) Multiome HiCAR | 625 | |
| chr19:49,676,058–49,678,754 | 164.6 kb | Distal (>10kb) Multiome HiCAR | 1033 | |
| chr19:49,680,433–49,681,147 | 168.4 kb | Distal (>10kb) Multiome | 435 | |
| chr19:49,690,485–49,691,761 | 178.7 kb | Distal (>10kb) Multiome | 327 | |
| chr19:49,746,188–49,746,748 | 234.1 kb | Distal (>10kb) Multiome | 283 | |
| chr19:49,766,231–49,767,440 | 254.3 kb | Distal (>10kb) Multiome | 718 | |
| chr19:49,802,146–49,802,787 | 290.1 kb | Distal (>10kb) Multiome | 200 | |
| chr19:49,805,226–49,805,871 | 293.2 kb | Distal (>10kb) Multiome | 245 | |
| chr19:49,808,201–49,809,746 | 296.6 kb | Distal (>10kb) Multiome | 509 | |
| chr19:49,812,926–49,813,834 | 301.1 kb | Distal (>10kb) Multiome | 650 |
Genomic view of the FCGRT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.