This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBXO6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:11,478,503–11,480,383 | 185.2 kb | Distal (>10kb) Multiome | 732 | |
| chr1:11,650,273–11,650,925 | 13.6 kb | Distal (>10kb) Multiome | 495 | |
| chr1:11,653,905–11,655,506 | 9.4 kb | Proximal (<10kb) Multiome | 476 | |
| chr1:11,663,895–11,664,883 | 101 bp | At TSS Multiome | 644 | |
| chr1:11,680,428–11,681,928 | 17.0 kb | Distal (>10kb) Multiome | 820 | |
| chr1:11,682,348–11,682,757 | 18.5 kb | Distal (>10kb) Multiome | 94 | |
| chr1:11,690,815–11,692,563 | 27.5 kb | Distal (>10kb) Multiome | 361 | |
| chr1:11,735,752–11,736,686 | 72.0 kb | Distal (>10kb) Multiome | 714 | |
| chr1:11,784,926–11,785,439 | 121.1 kb | Distal (>10kb) Multiome | 531 | |
| chr1:11,802,827–11,804,002 | 139.4 kb | Distal (>10kb) Multiome | 507 | |
| chr1:11,805,133–11,806,702 | 141.9 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:11,907,175–11,910,389 | 245.5 kb | Distal (>10kb) Multiome | 1299 | |
| chr1:11,925,969–11,926,788 | 262.3 kb | Distal (>10kb) Multiome | 632 | |
| chr1:11,934,261–11,935,008 | 270.5 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the FBXO6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.