FBXO46

F-box protein 46 | 20D7-FC4, Fbx46, FBXO34L

Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Member of: DE-10

Biological processes 6 terms

SCF ubiquitin ligase complex (GO:0019005)SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)protein binding (GO:0005515)protein ubiquitination (GO:0016567)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)

Expression (TPM)

TFs regulating FBXO46 0 TFs

Transcription factors with Perturb-seq knockdown data for FBXO46. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO46 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FBXO46

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO46, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:45,439,539–45,440,189	291.1 kb	Distal (>10kb) Multiome	718
chr19:45,443,052–45,444,768	287.4 kb	Distal (>10kb) Multiome	857
chr19:45,450,695–45,451,265	280.0 kb	Distal (>10kb) Multiome	515
chr19:45,455,706–45,456,201	274.9 kb	Distal (>10kb) Multiome	776
chr19:45,467,169–45,468,696	263.2 kb	Distal (>10kb) Multiome	686
chr19:45,468,843–45,470,312	261.5 kb	Distal (>10kb) Multiome	769
chr19:45,478,416–45,479,276	252.1 kb	Distal (>10kb) Multiome	809
chr19:45,485,144–45,486,070	245.3 kb	Distal (>10kb) Multiome	659
chr19:45,492,647–45,493,344	238.0 kb	Distal (>10kb) Multiome	522
chr19:45,496,247–45,497,677	233.8 kb	Distal (>10kb) Multiome	742
chr19:45,498,270–45,499,916	231.3 kb	Distal (>10kb) Multiome	464
chr19:45,506,243–45,507,963	224.2 kb	Distal (>10kb) Multiome	969
chr19:45,508,291–45,509,751	222.2 kb	Distal (>10kb) Multiome	670
chr19:45,528,315–45,529,353	202.0 kb	Distal (>10kb) Multiome	425
chr19:45,584,026–45,585,251	146.2 kb	Distal (>10kb) Multiome	907
chr19:45,607,096–45,607,695	123.5 kb	Distal (>10kb) Multiome	526
chr19:45,615,654–45,616,944	114.7 kb	Distal (>10kb) Multiome	480
chr19:45,632,406–45,633,148	98.2 kb	Distal (>10kb) Multiome	358
chr19:45,638,965–45,639,696	91.6 kb	Distal (>10kb) Multiome	477
chr19:45,640,813–45,642,557	88.6 kb	Distal (>10kb) Multiome	865
chr19:45,643,187–45,644,012	87.3 kb	Distal (>10kb) Multiome	542
chr19:45,645,389–45,646,343	85.0 kb	Distal (>10kb) Multiome	566
chr19:45,667,856–45,668,417	62.8 kb	Distal (>10kb) Multiome	386
chr19:45,668,914–45,669,719	61.5 kb	Distal (>10kb) Multiome	611
chr19:45,670,481–45,671,446	59.9 kb	Distal (>10kb) Multiome	361
chr19:45,676,875–45,678,209	53.4 kb	Distal (>10kb) Multiome	418
chr19:45,681,530–45,682,004	49.2 kb	Distal (>10kb) Multiome	648
chr19:45,691,622–45,693,062	38.5 kb	Distal (>10kb) Multiome	943
chr19:45,716,851–45,718,343	13.4 kb	Distal (>10kb) Multiome	895
chr19:45,729,716–45,730,097	798 bp	At TSS	168
chr19:45,730,200–45,731,219	88 bp	At TSS Multiome	740
chr19:45,767,223–45,771,892	38.5 kb	Distal (>10kb) Multiome	1161
chr19:45,779,258–45,780,150	48.7 kb	Distal (>10kb) Multiome	445
chr19:45,792,338–45,793,273	62.0 kb	Distal (>10kb) Multiome	609
chr19:45,815,484–45,818,073	85.0 kb	Distal (>10kb) Multiome	623
chr19:45,862,559–45,864,765	133.5 kb	Distal (>10kb) Multiome	976
chr19:45,881,480–45,883,645	151.2 kb	Distal (>10kb) Multiome	990
chr19:45,885,092–45,887,294	155.8 kb	Distal (>10kb) Multiome	913
chr19:45,901,212–45,903,471	172.0 kb	Distal (>10kb) Multiome	780
chr19:45,952,967–45,953,485	222.2 kb	Distal (>10kb) Multiome	329
chr19:45,973,761–45,974,227	243.2 kb	Distal (>10kb) Multiome	201
chr19:45,994,774–45,995,740	264.4 kb	Distal (>10kb) Multiome	660
chr19:46,014,941–46,015,784	284.5 kb	Distal (>10kb) Multiome	220
chr19:46,016,414–46,017,078	286.0 kb	Distal (>10kb) Multiome	364

Genome Browser

Genomic view of the FBXO46 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.