Transcription factors with Perturb-seq knockdown data for FBXO38-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO38-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO38-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:148,090,303–148,091,251 | 293.1 kb | Distal (>10kb) Multiome | 206 | |
| chr5:148,374,702–148,375,240 | 8.7 kb | Proximal (<10kb) | 255 | |
| chr5:148,383,493–148,384,592 | 3 bp | At TSS Multiome | 873 | |
| chr5:148,393,194–148,393,645 | 9.3 kb | Proximal (<10kb) | 100 | |
| chr5:148,397,697–148,398,256 | 14.1 kb | Distal (>10kb) Multiome | 294 | |
| chr5:148,454,537–148,455,034 | 70.9 kb | Distal (>10kb) Multiome | 76 |
Genomic view of the FBXO38-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.