This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for FBXO31. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO31 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO31, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:87,264,671–87,265,109 | 118.8 kb | Distal (>10kb) Multiome | 88 | |
| chr16:87,278,468–87,279,093 | 105.0 kb | Distal (>10kb) Multiome | 284 | |
| chr16:87,305,529–87,306,047 | 77.9 kb | Distal (>10kb) Multiome | 282 | |
| chr16:87,316,905–87,317,759 | 66.4 kb | Distal (>10kb) Multiome | 945 | |
| chr16:87,382,568–87,384,888 | 144 bp | At TSS Multiome | 1122 | |
| chr16:87,388,081–87,388,660 | 4.7 kb | Proximal (<10kb) Multiome | 794 | |
| chr16:87,391,244–87,393,452 | 8.4 kb | Proximal (<10kb) Multiome | 1038 | |
| chr16:87,492,670–87,493,484 | 109.3 kb | Distal (>10kb) Multiome | 652 | |
| chr16:87,601,726–87,602,537 | 218.5 kb | Distal (>10kb) Multiome | 217 |
Genomic view of the FBXO31 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.