This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBXO30. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO30 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO30, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:145,531,555–145,532,917 | 282.7 kb | Distal (>10kb) Multiome | 311 | |
| chr6:145,734,589–145,736,178 | 79.6 kb | Distal (>10kb) Multiome | 1204 | |
| chr6:145,813,767–145,815,849 | 64 bp | At TSS Multiome | 1126 | |
| chr6:145,815,945–145,816,140 | 1.1 kb | Proximal (<10kb) | 39 | |
| chr6:145,963,575–145,965,229 | 149.6 kb | Distal (>10kb) Multiome | 911 | |
| chr6:146,027,603–146,028,698 | 213.5 kb | Distal (>10kb) Multiome | 683 |
Genomic view of the FBXO30 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.