This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBXO3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:33,699,853–33,701,513 | 73.6 kb | Distal (>10kb) Multiome | 711 | |
| chr11:33,735,423–33,737,268 | 38.0 kb | Distal (>10kb) Multiome | 769 | |
| chr11:33,773,812–33,775,173 | 21 bp | At TSS Multiome | 606 | |
| chr11:33,779,747–33,780,070 | 5.2 kb | Proximal (<10kb) | 40 | |
| chr11:33,802,236–33,803,023 | 28.2 kb | Distal (>10kb) Multiome | 464 | |
| chr11:33,829,198–33,829,839 | 55.0 kb | Distal (>10kb) Multiome | 203 | |
| chr11:33,868,762–33,870,240 | 95.2 kb | Distal (>10kb) Multiome | 416 | |
| chr11:34,051,095–34,052,918 | 277.1 kb | Distal (>10kb) Multiome | 940 |
Genomic view of the FBXO3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.