This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for FBXO22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:75,624,816–75,626,356 | 278.1 kb | Distal (>10kb) Multiome | 987 | |
| chr15:75,639,562–75,640,798 | 263.5 kb | Distal (>10kb) Multiome | 999 | |
| chr15:75,647,017–75,648,674 | 256.0 kb | Distal (>10kb) Multiome | 795 | |
| chr15:75,672,794–75,673,400 | 230.9 kb | Distal (>10kb) Multiome | 226 | |
| chr15:75,712,716–75,713,248 | 191.0 kb | Distal (>10kb) Multiome | 318 | |
| chr15:75,738,177–75,739,332 | 165.1 kb | Distal (>10kb) Multiome | 611 | |
| chr15:75,758,383–75,758,865 | 145.3 kb | Distal (>10kb) Multiome | 550 | |
| chr15:75,823,901–75,824,543 | 79.8 kb | Distal (>10kb) Multiome | 98 | |
| chr15:75,842,738–75,844,503 | 60.6 kb | Distal (>10kb) Multiome | 842 | |
| chr15:75,902,290–75,902,483 | 1.4 kb | Proximal (<10kb) | 175 | |
| chr15:75,903,363–75,904,635 | 65 bp | At TSS Multiome | 958 | |
| chr15:76,033,743–76,034,907 | 130.4 kb | Distal (>10kb) Multiome | 131 | |
| chr15:76,058,953–76,060,346 | 155.9 kb | Distal (>10kb) Multiome | 463 | |
| chr15:76,139,361–76,140,331 | 235.9 kb | Distal (>10kb) Multiome | 257 |
Genomic view of the FBXO22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.