FBXL6

F-box and leucine rich repeat protein 6 | FBL6

This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Member of: DE-1

Biological processes 7 terms

SCF ubiquitin ligase complex (GO:0019005)SCF ubiquitin ligase complex (GO:0019005)SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)protein binding (GO:0005515)proteolysis (GO:0006508)ubiquitin-protein transferase activity (GO:0004842)

Expression (TPM)

TFs regulating FBXL6 0 TFs

Transcription factors with Perturb-seq knockdown data for FBXL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FBXL6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:144,060,259–144,061,087	297.7 kb	Distal (>10kb) Multiome	727
chr8:144,078,142–144,079,235	279.8 kb	Distal (>10kb) Multiome	912
chr8:144,082,187–144,083,105	275.9 kb	Distal (>10kb) Multiome	763
chr8:144,094,454–144,095,491	263.5 kb	Distal (>10kb) Multiome	798
chr8:144,103,485–144,105,242	254.1 kb	Distal (>10kb) Multiome	1033
chr8:144,108,038–144,108,663	250.1 kb	Distal (>10kb) Multiome	137
chr8:144,137,565–144,138,500	220.7 kb	Distal (>10kb) Multiome	817
chr8:144,146,820–144,149,073	210.5 kb	Distal (>10kb) Multiome	790
chr8:144,266,293–144,267,098	92.0 kb	Distal (>10kb) Multiome	162
chr8:144,290,981–144,292,410	67.0 kb	Distal (>10kb) Multiome	716
chr8:144,315,833–144,316,450	42.3 kb	Distal (>10kb) Multiome	396
chr8:144,325,768–144,327,719	31.6 kb	Distal (>10kb) Multiome	1016
chr8:144,331,281–144,333,847	26.5 kb	Distal (>10kb) Multiome	406
chr8:144,336,102–144,339,119	21.6 kb	Distal (>10kb) Multiome	922
chr8:144,353,907–144,355,227	3.9 kb	Proximal (<10kb) Multiome	280
chr8:144,357,674–144,358,036	435 bp	At TSS	305
chr8:144,358,142–144,359,070	108 bp	At TSS Multiome	719
chr8:144,369,349–144,369,916	11.2 kb	Distal (>10kb) Multiome HiCAR	204
chr8:144,372,497–144,372,883	14.2 kb	Distal (>10kb) Multiome	160
chr8:144,372,993–144,375,084	15.5 kb	Distal (>10kb) Multiome	903
chr8:144,408,968–144,410,189	51.0 kb	Distal (>10kb) Multiome	920
chr8:144,427,691–144,429,571	70.1 kb	Distal (>10kb) Multiome HiCAR	1000
chr8:144,443,691–144,445,047	85.9 kb	Distal (>10kb) Multiome HiCAR	743
chr8:144,462,568–144,463,422	104.4 kb	Distal (>10kb) Multiome	548
chr8:144,463,885–144,468,178	107.3 kb	Distal (>10kb) Multiome	910
chr8:144,471,960–144,474,391	114.1 kb	Distal (>10kb) Multiome	482
chr8:144,474,517–144,476,543	117.4 kb	Distal (>10kb) Multiome	321
chr8:144,477,277–144,478,749	119.5 kb	Distal (>10kb) Multiome	679
chr8:144,478,851–144,479,509	120.8 kb	Distal (>10kb) Multiome	392
chr8:144,483,979–144,484,843	125.9 kb	Distal (>10kb) Multiome	125
chr8:144,495,748–144,496,431	137.6 kb	Distal (>10kb) Multiome	131
chr8:144,500,182–144,501,505	142.5 kb	Distal (>10kb) Multiome	484
chr8:144,507,995–144,510,268	150.4 kb	Distal (>10kb) Multiome	1067
chr8:144,517,168–144,518,442	159.4 kb	Distal (>10kb) Multiome	637
chr8:144,521,935–144,523,450	164.0 kb	Distal (>10kb) Multiome	663
chr8:144,524,105–144,525,099	166.2 kb	Distal (>10kb) Multiome	264
chr8:144,526,399–144,529,305	168.6 kb	Distal (>10kb) Multiome	934
chr8:144,529,455–144,530,630	171.7 kb	Distal (>10kb) Multiome	284
chr8:144,580,290–144,581,657	222.3 kb	Distal (>10kb) Multiome	271

Genome Browser

Genomic view of the FBXL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.