This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for FBXL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:15,478,821–15,479,992 | 202.3 kb | Distal (>10kb) Multiome HiCAR | 573 | |
| chr4:15,650,016–15,650,237 | 5.1 kb | Proximal (<10kb) | 335 | |
| chr4:15,654,616–15,656,736 | 26.3 kb | Distal (>10kb) Multiome | 937 | |
| chr4:15,681,242–15,682,290 | 24 bp | At TSS Multiome | 960 | |
| chr4:15,684,595–15,684,948 | 2.9 kb | Proximal (<10kb) | 28 | |
| chr4:15,690,487–15,690,812 | 8.8 kb | Proximal (<10kb) | 229 | |
| chr4:15,702,743–15,703,565 | 21.5 kb | Distal (>10kb) Multiome | 208 | |
| chr4:15,905,937–15,906,566 | 224.5 kb | Distal (>10kb) Multiome | 376 |
Genomic view of the FBXL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.