Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FBXL20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:39,152,575–39,154,848 | 248.1 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:39,164,617–39,165,311 | 237.6 kb | Distal (>10kb) Multiome | 371 | |
| chr17:39,197,170–39,198,193 | 204.8 kb | Distal (>10kb) Multiome | 515 | |
| chr17:39,199,726–39,200,760 | 202.4 kb | Distal (>10kb) Multiome | 947 | |
| chr17:39,209,452–39,209,995 | 192.7 kb | Distal (>10kb) Multiome | 268 | |
| chr17:39,225,532–39,226,262 | 176.5 kb | Distal (>10kb) Multiome | 235 | |
| chr17:39,244,638–39,245,241 | 157.6 kb | Distal (>10kb) Multiome HiCAR | 348 | |
| chr17:39,400,997–39,402,766 | 85 bp | At TSS Multiome | 898 | |
| chr17:39,450,919–39,451,504 | 48.8 kb | Distal (>10kb) Multiome | 722 | |
| chr17:39,461,043–39,462,217 | 59.0 kb | Distal (>10kb) Multiome | 1026 | |
| chr17:39,573,453–39,574,243 | 171.3 kb | Distal (>10kb) Multiome | 520 | |
| chr17:39,636,769–39,637,600 | 234.6 kb | Distal (>10kb) Multiome | 853 | |
| chr17:39,652,588–39,653,348 | 250.5 kb | Distal (>10kb) Multiome | 263 | |
| chr17:39,668,234–39,668,690 | 266.0 kb | Distal (>10kb) Multiome | 706 | |
| chr17:39,687,710–39,688,437 | 285.5 kb | Distal (>10kb) Multiome | 800 | |
| chr17:39,695,905–39,696,636 | 293.8 kb | Distal (>10kb) Multiome | 499 | |
| chr17:39,699,516–39,700,527 | 297.4 kb | Distal (>10kb) Multiome | 528 |
Genomic view of the FBXL20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.