Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FBXL12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,140,232–9,140,885 | 687.4 kb | Distal (>10kb) Multiome HiCAR | 722 | |
| chr19:9,538,339–9,539,009 | 289.1 kb | Distal (>10kb) Multiome | 759 | |
| chr19:9,582,064–9,582,785 | 245.3 kb | Distal (>10kb) Multiome HiCAR | 99 | |
| chr19:9,584,055–9,584,863 | 243.2 kb | Distal (>10kb) Multiome HiCAR | 801 | |
| chr19:9,620,792–9,622,027 | 206.5 kb | Distal (>10kb) Multiome HiCAR | 856 | |
| chr19:9,674,791–9,675,456 | 152.7 kb | Distal (>10kb) Multiome | 793 | |
| chr19:9,768,230–9,769,267 | 59.1 kb | Distal (>10kb) Multiome | 893 | |
| chr19:9,784,209–9,786,632 | 42.0 kb | Distal (>10kb) Multiome | 727 | |
| chr19:9,791,515–9,793,483 | 35.0 kb | Distal (>10kb) Multiome | 507 | |
| chr19:9,818,302–9,820,113 | 8.5 kb | Proximal (<10kb) Multiome | 870 | |
| chr19:9,827,304–9,828,194 | 2 bp | At TSS Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 7.3 kb | Proximal (<10kb) Multiome | 681 | |
| chr19:9,913,549–9,914,444 | 85.9 kb | Distal (>10kb) Multiome | 322 | |
| chr19:9,914,501–9,914,999 | 87.0 kb | Distal (>10kb) Multiome | 587 | |
| chr19:9,933,993–9,934,841 | 106.5 kb | Distal (>10kb) Multiome | 425 | |
| chr19:9,935,627–9,937,234 | 108.7 kb | Distal (>10kb) Multiome | 297 | |
| chr19:10,027,570–10,028,022 | 200.0 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,086,000–10,086,942 | 258.5 kb | Distal (>10kb) Multiome | 614 | |
| chr19:10,095,848–10,096,951 | 268.4 kb | Distal (>10kb) Multiome | 572 | |
| chr19:10,106,123–10,106,748 | 278.5 kb | Distal (>10kb) Multiome | 842 | |
| chr19:10,113,011–10,113,478 | 285.4 kb | Distal (>10kb) Multiome | 511 | |
| chr19:10,119,464–10,120,287 | 292.1 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the FBXL12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.