Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:94,374,230–94,375,026 | 265.0 kb | Distal (>10kb) Multiome | 332 | |
| chr9:94,552,994–94,555,388 | 84.7 kb | Distal (>10kb) Multiome | 631 | |
| chr9:94,639,019–94,639,691 | 137 bp | At TSS Multiome | 277 | |
| chr9:94,639,882–94,640,360 | 657 bp | At TSS Multiome | 156 | |
| chr9:94,726,305–94,727,294 | 87.2 kb | Distal (>10kb) Multiome | 856 |
Genomic view of the FBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.