Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBLN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBLN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBLN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:45,239,931–45,241,595 | 262.0 kb | Distal (>10kb) Multiome | 482 | |
| chr22:45,267,970–45,269,955 | 233.7 kb | Distal (>10kb) Multiome | 600 | |
| chr22:45,309,117–45,310,833 | 193.1 kb | Distal (>10kb) Multiome | 821 | |
| chr22:45,413,403–45,414,177 | 89.2 kb | Distal (>10kb) Multiome | 453 | |
| chr22:45,435,549–45,435,992 | 67.2 kb | Distal (>10kb) Multiome | 461 | |
| chr22:45,443,959–45,444,454 | 58.7 kb | Distal (>10kb) Multiome | 24 | |
| chr22:45,493,315–45,493,689 | 9.3 kb | Proximal (<10kb) | 61 | |
| chr22:45,502,050–45,504,452 | 263 bp | At TSS Multiome | 701 | |
| chr22:45,504,931–45,505,362 | 2.0 kb | Proximal (<10kb) | 128 | |
| chr22:45,629,603–45,630,068 | 126.9 kb | Distal (>10kb) Multiome | 249 | |
| chr22:45,645,487–45,646,063 | 142.8 kb | Distal (>10kb) Multiome | 469 | |
| chr22:45,671,242–45,672,505 | 168.9 kb | Distal (>10kb) Multiome | 734 |
Genomic view of the FBLN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.