Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAXC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAXC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAXC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:99,219,557–99,220,312 | 129.7 kb | Distal (>10kb) Multiome | 105 | |
| chr6:99,334,622–99,335,005 | 7.9 kb | Proximal (<10kb) | 136 | |
| chr6:99,347,512–99,347,692 | 4.6 kb | Proximal (<10kb) | 14 | |
| chr6:99,348,770–99,350,367 | 125 bp | At TSS Multiome | 615 | |
| chr6:99,353,242–99,353,409 | 3.6 kb | Proximal (<10kb) | 45 | |
| chr6:99,393,480–99,394,529 | 44.3 kb | Distal (>10kb) Multiome | 782 | |
| chr6:99,424,727–99,426,355 | 75.8 kb | Distal (>10kb) Multiome | 975 | |
| chr6:99,514,702–99,516,390 | 165.8 kb | Distal (>10kb) Multiome | 945 | |
| chr6:99,520,676–99,522,033 | 171.4 kb | Distal (>10kb) Multiome | 822 | |
| chr6:99,567,957–99,569,279 | 219.0 kb | Distal (>10kb) Multiome | 1064 | |
| chr6:99,588,272–99,589,608 | 239.2 kb | Distal (>10kb) Multiome | 545 | |
| chr6:99,602,753–99,604,086 | 254.0 kb | Distal (>10kb) Multiome | 376 | |
| chr6:99,612,582–99,615,086 | 264.0 kb | Distal (>10kb) Multiome | 533 | |
| chr6:99,618,513–99,619,470 | 269.2 kb | Distal (>10kb) Multiome | 225 |
Genomic view of the FAXC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.