This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:186,554,397–186,556,441 | 171.1 kb | Distal (>10kb) Multiome | 443 | |
| chr4:186,687,881–186,688,846 | 38.3 kb | Distal (>10kb) Multiome | 273 | |
| chr4:186,720,054–186,720,221 | 3.6 kb | Proximal (<10kb) | 63 | |
| chr4:186,723,135–186,725,377 | 3.0 kb | Proximal (<10kb) Multiome | 681 | |
| chr4:186,725,478–186,727,649 | 34 bp | At TSS Multiome | 868 | |
| chr4:186,728,063–186,728,444 | 4.2 kb | Proximal (<10kb) | 152 | |
| chr4:186,728,672–186,728,863 | 4.8 kb | Proximal (<10kb) | 242 | |
| chr4:186,734,251–186,735,164 | 7.9 kb | Proximal (<10kb) Multiome | 90 | |
| chr4:186,888,840–186,889,769 | 162.5 kb | Distal (>10kb) Multiome | 230 | |
| chr4:187,505,043–187,506,255 | 778.9 kb | Distal (>10kb) Multiome HiCAR | 169 | |
| chr4:188,195,903–188,196,923 | 1469.7 kb | Distal (>10kb) Multiome HiCAR | 183 |
Genomic view of the FAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.