This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for FASTKD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FASTKD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FASTKD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:206,611,577–206,612,198 | 153.5 kb | Distal (>10kb) Multiome | 113 | |
| chr2:206,641,860–206,642,929 | 122.8 kb | Distal (>10kb) Multiome | 253 | |
| chr2:206,764,811–206,766,089 | 100 bp | At TSS Multiome | 844 | |
| chr2:206,954,806–206,955,846 | 190.0 kb | Distal (>10kb) Multiome | 169 |
Genomic view of the FASTKD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.