Enables RNA binding activity. Involved in mitochondrial RNA metabolic process and regulation of mitochondrial mRNA stability. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FASTKD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FASTKD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FASTKD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:169,361,649–169,362,728 | 211.9 kb | Distal (>10kb) Multiome | 485 | |
| chr2:169,363,554–169,365,015 | 209.3 kb | Distal (>10kb) Multiome | 538 | |
| chr2:169,479,264–169,479,982 | 94.3 kb | Distal (>10kb) Multiome | 907 | |
| chr2:169,573,179–169,574,073 | 24 bp | At TSS Multiome | 834 | |
| chr2:169,584,221–169,584,891 | 10.6 kb | Distal (>10kb) Multiome | 994 | |
| chr2:169,694,097–169,694,854 | 120.7 kb | Distal (>10kb) Multiome | 898 | |
| chr2:169,733,252–169,734,532 | 160.1 kb | Distal (>10kb) Multiome | 735 | |
| chr2:169,789,706–169,790,238 | 216.1 kb | Distal (>10kb) Multiome | 539 | |
| chr2:169,798,658–169,799,453 | 225.1 kb | Distal (>10kb) Multiome | 794 | |
| chr2:169,824,413–169,825,252 | 251.1 kb | Distal (>10kb) Multiome | 946 | |
| chr2:169,827,076–169,828,199 | 253.6 kb | Distal (>10kb) Multiome | 760 |
Genomic view of the FASTKD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.