The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FASN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FASN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FASN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,832,473–81,833,976 | 265.0 kb | Distal (>10kb) Multiome | 1015 | |
| chr17:81,859,762–81,861,595 | 237.4 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:81,868,421–81,868,978 | 229.7 kb | Distal (>10kb) Multiome | 577 | |
| chr17:81,869,000–81,872,289 | 227.0 kb | Distal (>10kb) Multiome | 1136 | |
| chr17:81,891,143–81,892,257 | 206.5 kb | Distal (>10kb) Multiome | 969 | |
| chr17:81,910,443–81,911,980 | 186.7 kb | Distal (>10kb) Multiome | 806 | |
| chr17:81,917,586–81,918,522 | 180.1 kb | Distal (>10kb) Multiome | 619 | |
| chr17:81,923,285–81,923,863 | 174.8 kb | Distal (>10kb) Multiome | 399 | |
| chr17:81,926,141–81,929,133 | 170.4 kb | Distal (>10kb) Multiome | 1034 | |
| chr17:81,936,855–81,937,682 | 161.0 kb | Distal (>10kb) Multiome | 854 | |
| chr17:81,959,299–81,962,169 | 138.6 kb | Distal (>10kb) Multiome | 805 | |
| chr17:81,966,804–81,968,359 | 130.2 kb | Distal (>10kb) Multiome | 908 | |
| chr17:81,976,595–81,978,312 | 120.6 kb | Distal (>10kb) Multiome | 1001 | |
| chr17:82,019,856–82,020,391 | 78.2 kb | Distal (>10kb) Multiome | 436 | |
| chr17:82,022,355–82,024,111 | 75.2 kb | Distal (>10kb) Multiome | 898 | |
| chr17:82,029,976–82,032,662 | 66.4 kb | Distal (>10kb) Multiome | 695 | |
| chr17:82,036,902–82,037,961 | 60.7 kb | Distal (>10kb) Multiome | 892 | |
| chr17:82,051,387–82,052,184 | 46.5 kb | Distal (>10kb) Multiome | 479 | |
| chr17:82,065,558–82,066,150 | 32.5 kb | Distal (>10kb) Multiome | 967 | |
| chr17:82,095,514–82,096,334 | 1.9 kb | Proximal (<10kb) | 292 | |
| chr17:82,096,478–82,100,203 | 253 bp | At TSS Multiome | 1085 | |
| chr17:82,103,334–82,104,356 | 5.3 kb | Proximal (<10kb) Multiome | 672 | |
| chr17:82,106,298–82,106,759 | 8.1 kb | Proximal (<10kb) | 735 | |
| chr17:82,212,405–82,213,592 | 114.6 kb | Distal (>10kb) Multiome | 911 | |
| chr17:82,228,266–82,232,536 | 130.7 kb | Distal (>10kb) Multiome | 1048 | |
| chr17:82,272,608–82,274,062 | 175.4 kb | Distal (>10kb) Multiome | 943 | |
| chr17:82,278,488–82,279,226 | 180.6 kb | Distal (>10kb) Multiome | 229 | |
| chr17:82,292,400–82,293,256 | 194.6 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the FASN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.