The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for FAR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:13,462,425–13,464,206 | 205.5 kb | Distal (>10kb) Multiome | 858 | |
| chr11:13,487,045–13,487,538 | 181.3 kb | Distal (>10kb) Multiome | 325 | |
| chr11:13,606,521–13,607,137 | 61.8 kb | Distal (>10kb) Multiome | 85 | |
| chr11:13,667,826–13,669,520 | 221 bp | At TSS Multiome | 653 | |
| chr11:13,678,257–13,678,438 | 9.5 kb | Proximal (<10kb) | 10 | |
| chr11:13,777,387–13,777,953 | 108.9 kb | Distal (>10kb) Multiome | 153 | |
| chr11:13,962,160–13,964,858 | 294.1 kb | Distal (>10kb) Multiome | 311 |
Genomic view of the FAR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.