Predicted to enable protein kinase binding activity. Involved in BMP signaling pathway. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM83G. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM83G upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM83G, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:18,785,755–18,786,420 | 218.6 kb | Distal (>10kb) Multiome | 91 | |
| chr17:18,855,845–18,856,439 | 148.5 kb | Distal (>10kb) Multiome | 582 | |
| chr17:18,857,671–18,858,643 | 146.7 kb | Distal (>10kb) Multiome | 600 | |
| chr17:19,003,639–19,005,123 | 392 bp | At TSS Multiome | 733 | |
| chr17:19,237,368–19,238,388 | 232.7 kb | Distal (>10kb) Multiome | 509 |
Genomic view of the FAM83G locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.