Transcription factors with Perturb-seq knockdown data for FAM184B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM184B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM184B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:17,511,108–17,512,753 | 269.5 kb | Distal (>10kb) Multiome | 724 | |
| chr4:17,576,452–17,578,383 | 204.3 kb | Distal (>10kb) Multiome | 874 | |
| chr4:17,613,634–17,615,353 | 167.0 kb | Distal (>10kb) Multiome | 740 | |
| chr4:17,636,469–17,637,277 | 144.7 kb | Distal (>10kb) Multiome | 322 | |
| chr4:17,780,838–17,782,239 | 10 bp | At TSS Multiome | 374 | |
| chr4:17,810,219–17,811,664 | 29.2 kb | Distal (>10kb) Multiome | 935 | |
| chr4:18,020,217–18,023,062 | 240.4 kb | Distal (>10kb) Multiome | 967 |
Genomic view of the FAM184B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.