Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM171A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM171A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM171A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:44,066,017–44,066,857 | 297.2 kb | Distal (>10kb) Multiome | 722 | |
| chr17:44,070,107–44,071,340 | 293.1 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:44,095,480–44,096,263 | 267.9 kb | Distal (>10kb) Multiome | 713 | |
| chr17:44,110,949–44,111,605 | 252.6 kb | Distal (>10kb) Multiome | 856 | |
| chr17:44,122,999–44,124,340 | 240.0 kb | Distal (>10kb) Multiome | 883 | |
| chr17:44,141,505–44,142,741 | 222.0 kb | Distal (>10kb) Multiome | 857 | |
| chr17:44,168,259–44,168,849 | 195.2 kb | Distal (>10kb) Multiome | 475 | |
| chr17:44,186,111–44,187,514 | 177.0 kb | Distal (>10kb) Multiome | 917 | |
| chr17:44,198,550–44,201,037 | 163.7 kb | Distal (>10kb) Multiome | 868 | |
| chr17:44,210,257–44,210,930 | 153.3 kb | Distal (>10kb) Multiome | 568 | |
| chr17:44,218,107–44,221,629 | 145.2 kb | Distal (>10kb) Multiome | 936 | |
| chr17:44,221,765–44,222,816 | 141.5 kb | Distal (>10kb) Multiome | 597 | |
| chr17:44,307,755–44,309,164 | 55.3 kb | Distal (>10kb) Multiome | 726 | |
| chr17:44,314,945–44,315,776 | 48.6 kb | Distal (>10kb) Multiome | 273 | |
| chr17:44,316,273–44,316,728 | 47.4 kb | Distal (>10kb) Multiome | 183 | |
| chr17:44,324,218–44,325,841 | 38.9 kb | Distal (>10kb) Multiome | 852 | |
| chr17:44,326,610–44,327,149 | 36.8 kb | Distal (>10kb) Multiome | 599 | |
| chr17:44,344,826–44,346,001 | 18.6 kb | Distal (>10kb) Multiome | 837 | |
| chr17:44,353,667–44,355,182 | 9.1 kb | Proximal (<10kb) Multiome | 393 | |
| chr17:44,363,447–44,364,077 | 18 bp | At TSS Multiome | 502 | |
| chr17:44,369,581–44,369,836 | 5.7 kb | Proximal (<10kb) | 162 | |
| chr17:44,374,688–44,375,216 | 11.0 kb | Distal (>10kb) Multiome | 299 | |
| chr17:44,384,542–44,386,175 | 21.6 kb | Distal (>10kb) Multiome | 553 | |
| chr17:44,502,912–44,504,091 | 139.7 kb | Distal (>10kb) Multiome | 999 | |
| chr17:44,539,724–44,540,529 | 176.3 kb | Distal (>10kb) Multiome | 135 | |
| chr17:44,543,007–44,544,301 | 179.4 kb | Distal (>10kb) Multiome | 384 | |
| chr17:44,556,129–44,558,277 | 193.5 kb | Distal (>10kb) Multiome | 696 | |
| chr17:44,608,340–44,608,975 | 244.7 kb | Distal (>10kb) Multiome | 208 | |
| chr17:44,628,394–44,629,188 | 264.8 kb | Distal (>10kb) Multiome | 285 | |
| chr17:44,656,036–44,656,706 | 292.5 kb | Distal (>10kb) Multiome | 280 |
Genomic view of the FAM171A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.