Transcription factors with Perturb-seq knockdown data for FAM167A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM167A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM167A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:11,200,019–11,201,991 | 265.3 kb | Distal (>10kb) Multiome | 601 | |
| chr8:11,246,809–11,247,816 | 219.5 kb | Distal (>10kb) Multiome | 167 | |
| chr8:11,283,848–11,285,272 | 182.2 kb | Distal (>10kb) Multiome | 985 | |
| chr8:11,346,754–11,348,253 | 119.2 kb | Distal (>10kb) Multiome | 547 | |
| chr8:11,439,886–11,440,775 | 26.4 kb | Distal (>10kb) Multiome HiCAR | 160 | |
| chr8:11,466,250–11,468,072 | 959 bp | At TSS Multiome | 594 | |
| chr8:11,563,746–11,564,943 | 98.0 kb | Distal (>10kb) Multiome | 644 | |
| chr8:11,617,248–11,618,158 | 151.0 kb | Distal (>10kb) Multiome | 126 | |
| chr8:11,632,784–11,633,414 | 166.4 kb | Distal (>10kb) Multiome | 233 | |
| chr8:11,642,077–11,643,101 | 175.9 kb | Distal (>10kb) Multiome | 247 | |
| chr8:11,660,832–11,661,535 | 194.5 kb | Distal (>10kb) Multiome | 21 | |
| chr8:11,682,733–11,683,887 | 216.4 kb | Distal (>10kb) Multiome | 157 | |
| chr8:11,702,714–11,704,461 | 236.4 kb | Distal (>10kb) Multiome | 687 | |
| chr8:11,708,271–11,710,646 | 243.4 kb | Distal (>10kb) Multiome | 246 | |
| chr8:11,736,329–11,736,895 | 269.8 kb | Distal (>10kb) Multiome | 615 | |
| chr8:11,743,316–11,744,611 | 277.5 kb | Distal (>10kb) Multiome | 243 |
Genomic view of the FAM167A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.