Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM110B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM110B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM110B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:57,990,871–57,991,586 | 2.9 kb | Proximal (<10kb) | 106 | |
| chr8:57,993,081–57,993,302 | 1.2 kb | Proximal (<10kb) | 90 | |
| chr8:57,994,086–57,995,655 | 141 bp | At TSS Multiome | 441 | |
| chr8:57,997,050–57,997,246 | 2.5 kb | Proximal (<10kb) | 195 | |
| chr8:58,145,442–58,146,386 | 151.3 kb | Distal (>10kb) Multiome | 337 |
Genomic view of the FAM110B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.