The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FADS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FADS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FADS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:61,567,110–61,568,033 | 249.4 kb | Distal (>10kb) Multiome | 1078 | |
| chr11:61,580,454–61,581,871 | 235.7 kb | Distal (>10kb) Multiome | 760 | |
| chr11:61,587,343–61,588,726 | 228.7 kb | Distal (>10kb) Multiome | 271 | |
| chr11:61,680,168–61,680,631 | 136.7 kb | Distal (>10kb) Multiome | 532 | |
| chr11:61,747,560–61,748,157 | 69.1 kb | Distal (>10kb) Multiome | 493 | |
| chr11:61,752,190–61,753,041 | 64.4 kb | Distal (>10kb) Multiome | 329 | |
| chr11:61,777,258–61,777,759 | 39.5 kb | Distal (>10kb) Multiome | 149 | |
| chr11:61,792,046–61,793,394 | 24.2 kb | Distal (>10kb) Multiome | 896 | |
| chr11:61,814,541–61,817,407 | 1.7 kb | Proximal (<10kb) Multiome | 1128 | |
| chr11:61,827,285–61,829,337 | 11.0 kb | Distal (>10kb) Multiome | 728 | |
| chr11:61,871,019–61,871,621 | 54.3 kb | Distal (>10kb) Multiome | 443 | |
| chr11:61,890,974–61,892,214 | 74.7 kb | Distal (>10kb) Multiome | 619 | |
| chr11:61,898,986–61,899,424 | 82.3 kb | Distal (>10kb) Multiome | 498 | |
| chr11:61,917,152–61,917,983 | 100.6 kb | Distal (>10kb) Multiome | 465 | |
| chr11:61,955,466–61,956,219 | 138.8 kb | Distal (>10kb) Multiome | 217 | |
| chr11:61,966,654–61,968,718 | 150.7 kb | Distal (>10kb) Multiome | 939 | |
| chr11:61,971,541–61,972,360 | 155.0 kb | Distal (>10kb) Multiome | 877 |
Genomic view of the FADS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.