This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for F2RL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = F2RL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of F2RL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:76,548,249–76,549,423 | 270.3 kb | Distal (>10kb) Multiome | 149 | |
| chr5:76,715,026–76,716,740 | 103.0 kb | Distal (>10kb) Multiome | 666 | |
| chr5:76,789,270–76,790,249 | 29.1 kb | Distal (>10kb) Multiome | 123 | |
| chr5:76,808,093–76,808,802 | 10.6 kb | Distal (>10kb) Multiome | 237 | |
| chr5:76,809,142–76,809,507 | 9.5 kb | Proximal (<10kb) | 39 | |
| chr5:76,818,219–76,818,362 | 666 bp | At TSS | 36 | |
| chr5:76,818,476–76,819,940 | 71 bp | At TSS Multiome | 686 | |
| chr5:76,820,052–76,820,315 | 1.0 kb | Proximal (<10kb) | 228 | |
| chr5:76,821,065–76,821,450 | 2.0 kb | Proximal (<10kb) | 37 | |
| chr5:76,873,943–76,874,791 | 55.4 kb | Distal (>10kb) Multiome | 261 | |
| chr5:76,953,306–76,954,445 | 134.7 kb | Distal (>10kb) Multiome | 235 | |
| chr5:77,030,193–77,031,058 | 211.4 kb | Distal (>10kb) Multiome | 903 | |
| chr5:77,076,843–77,078,059 | 258.6 kb | Distal (>10kb) Multiome | 396 | |
| chr5:77,086,556–77,087,540 | 267.9 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the F2RL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.