This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for EXTL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXTL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXTL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:28,384,745–28,386,965 | 236.3 kb | Distal (>10kb) Multiome | 674 | |
| chr8:28,401,081–28,402,986 | 220.6 kb | Distal (>10kb) Multiome | 941 | |
| chr8:28,411,636–28,412,462 | 210.7 kb | Distal (>10kb) Multiome | 805 | |
| chr8:28,429,151–28,429,912 | 193.2 kb | Distal (>10kb) Multiome | 77 | |
| chr8:28,490,087–28,490,872 | 132.4 kb | Distal (>10kb) Multiome | 535 | |
| chr8:28,493,649–28,495,132 | 128.5 kb | Distal (>10kb) Multiome | 656 | |
| chr8:28,622,031–28,623,620 | 172 bp | At TSS Multiome | 828 | |
| chr8:28,631,375–28,631,679 | 8.6 kb | Proximal (<10kb) | 113 | |
| chr8:28,700,738–28,702,456 | 78.7 kb | Distal (>10kb) Multiome | 728 | |
| chr8:28,889,225–28,891,334 | 267.5 kb | Distal (>10kb) Multiome | 928 |
Genomic view of the EXTL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.