Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Involved in RNA catabolic process and RNA processing. Located in cytosol and nucleolus. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EXOSC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOSC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOSC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:44,729,240–44,729,901 | 246.7 kb | Distal (>10kb) Multiome | 780 | |
| chr3:44,761,326–44,762,300 | 214.5 kb | Distal (>10kb) Multiome | 966 | |
| chr3:44,861,375–44,862,600 | 114.4 kb | Distal (>10kb) Multiome | 765 | |
| chr3:44,975,358–44,976,703 | 61 bp | At TSS Multiome | 732 | |
| chr3:45,023,446–45,024,275 | 47.5 kb | Distal (>10kb) Multiome | 117 | |
| chr3:45,145,719–45,146,718 | 170.1 kb | Distal (>10kb) Multiome | 356 | |
| chr3:45,224,890–45,226,655 | 249.0 kb | Distal (>10kb) Multiome | 505 |
Genomic view of the EXOSC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.