The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for EXOC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:92,573,390–92,574,819 | 274.3 kb | Distal (>10kb) Multiome | 974 | |
| chr10:92,590,647–92,592,274 | 256.9 kb | Distal (>10kb) Multiome | 830 | |
| chr10:92,592,537–92,593,580 | 255.4 kb | Distal (>10kb) Multiome | 832 | |
| chr10:92,688,898–92,690,771 | 158.7 kb | Distal (>10kb) Multiome | 843 | |
| chr10:92,691,602–92,693,182 | 155.9 kb | Distal (>10kb) Multiome | 451 | |
| chr10:92,695,704–92,696,803 | 152.4 kb | Distal (>10kb) Multiome | 353 | |
| chr10:92,789,669–92,790,231 | 58.6 kb | Distal (>10kb) Multiome | 103 | |
| chr10:92,843,156–92,843,378 | 5.1 kb | Proximal (<10kb) | 273 | |
| chr10:92,848,153–92,849,292 | 29 bp | At TSS Multiome | 664 | |
| chr10:93,062,482–93,063,469 | 214.3 kb | Distal (>10kb) Multiome | 217 | |
| chr10:93,071,791–93,072,763 | 223.5 kb | Distal (>10kb) Multiome | 474 | |
| chr10:93,072,870–93,075,143 | 225.3 kb | Distal (>10kb) Multiome | 506 | |
| chr10:93,079,595–93,081,000 | 231.8 kb | Distal (>10kb) Multiome | 247 |
Genomic view of the EXOC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.