Transcription factors with Perturb-seq knockdown data for EXOC3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOC3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOC3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:188,610–189,107 | 254.4 kb | Distal (>10kb) Multiome | 472 | |
| chr5:217,613–219,286 | 224.9 kb | Distal (>10kb) Multiome | 692 | |
| chr5:271,018–272,107 | 171.7 kb | Distal (>10kb) Multiome | 866 | |
| chr5:320,742–322,619 | 121.6 kb | Distal (>10kb) Multiome HiCAR | 441 | |
| chr5:442,855–443,270 | at TSS | At TSS | 642 | |
| chr5:472,056–474,135 | 30.0 kb | Distal (>10kb) Multiome | 964 | |
| chr5:523,794–524,758 | 81.0 kb | Distal (>10kb) Multiome | 106 | |
| chr5:611,543–612,836 | 169.1 kb | Distal (>10kb) Multiome | 508 | |
| chr5:693,160–693,784 | 250.3 kb | Distal (>10kb) Multiome | 258 | |
| chr5:784,104–785,298 | 341.6 kb | Distal (>10kb) Multiome HiCAR | 316 |
Genomic view of the EXOC3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.