The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for ETNK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ETNK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ETNK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:203,861,102–203,862,191 | 290.4 kb | Distal (>10kb) Multiome HiCAR | 1090 | |
| chr1:204,065,124–204,065,934 | 86.6 kb | Distal (>10kb) Multiome | 155 | |
| chr1:204,072,301–204,075,400 | 79.0 kb | Distal (>10kb) Multiome | 828 | |
| chr1:204,078,065–204,078,999 | 73.7 kb | Distal (>10kb) Multiome | 348 | |
| chr1:204,079,587–204,080,941 | 71.5 kb | Distal (>10kb) Multiome | 492 | |
| chr1:204,084,225–204,084,936 | 67.5 kb | Distal (>10kb) Multiome | 439 | |
| chr1:204,108,483–204,109,315 | 43.2 kb | Distal (>10kb) Multiome | 151 | |
| chr1:204,128,928–204,129,568 | 22.8 kb | Distal (>10kb) Multiome HiCAR | 440 | |
| chr1:204,151,279–204,152,703 | 23 bp | At TSS Multiome | 556 | |
| chr1:204,213,764–204,214,668 | 62.2 kb | Distal (>10kb) Multiome HiCAR | 702 | |
| chr1:204,350,954–204,351,460 | 199.1 kb | Distal (>10kb) Multiome HiCAR | 138 | |
| chr1:204,377,771–204,378,537 | 226.1 kb | Distal (>10kb) Multiome HiCAR | 593 | |
| chr1:204,411,136–204,412,704 | 259.9 kb | Distal (>10kb) Multiome HiCAR | 939 | |
| chr1:204,446,280–204,446,835 | 294.4 kb | Distal (>10kb) Multiome | 311 | |
| chr1:204,506,146–204,507,240 | 354.5 kb | Distal (>10kb) Multiome HiCAR | 889 | |
| chr1:204,507,371–204,508,288 | 355.9 kb | Distal (>10kb) Multiome HiCAR | 508 |
Genomic view of the ETNK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.