This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ETFB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ETFB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ETFB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:51,107,794–51,109,056 | 257.9 kb | Distal (>10kb) Multiome | 750 | |
| chr19:51,311,132–51,312,279 | 54.8 kb | Distal (>10kb) Multiome | 99 | |
| chr19:51,327,535–51,328,038 | 38.5 kb | Distal (>10kb) Multiome | 288 | |
| chr19:51,338,815–51,340,814 | 26.5 kb | Distal (>10kb) Multiome | 827 | |
| chr19:51,362,718–51,363,402 | 3.0 kb | Proximal (<10kb) | 601 | |
| chr19:51,365,646–51,368,695 | 1.4 kb | Proximal (<10kb) Multiome | 1057 | |
| chr19:51,390,425–51,391,164 | 24.3 kb | Distal (>10kb) Multiome | 171 | |
| chr19:51,393,803–51,394,830 | 28.0 kb | Distal (>10kb) Multiome | 725 | |
| chr19:51,421,811–51,422,246 | 55.7 kb | Distal (>10kb) Multiome | 848 | |
| chr19:51,570,986–51,571,539 | 204.8 kb | Distal (>10kb) Multiome | 515 | |
| chr19:51,593,934–51,594,889 | 228.1 kb | Distal (>10kb) Multiome | 581 |
Genomic view of the ETFB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.