Enables calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endocytosis; endoplasmic reticulum-plasma membrane tethering; and lipid transport. Located in several cellular components, including cytoplasmic side of plasma membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ESYT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ESYT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ESYT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:158,587,414–158,588,855 | 241.7 kb | Distal (>10kb) Multiome | 384 | |
| chr7:158,704,389–158,705,515 | 124.6 kb | Distal (>10kb) Multiome | 894 | |
| chr7:158,828,327–158,830,454 | 998 bp | At TSS Multiome | 1104 | |
| chr7:158,855,976–158,857,103 | 27.0 kb | Distal (>10kb) Multiome | 944 | |
| chr7:158,863,230–158,864,395 | 34.4 kb | Distal (>10kb) Multiome | 534 | |
| chr7:158,976,471–158,977,488 | 147.6 kb | Distal (>10kb) Multiome | 458 | |
| chr7:159,030,257–159,031,567 | 201.3 kb | Distal (>10kb) Multiome | 560 |
Genomic view of the ESYT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.