Enables oxidoreductase activity. Involved in cell redox homeostasis and chaperone cofactor-dependent protein refolding. Located in Golgi lumen; endoplasmic reticulum; and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ERO1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERO1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERO1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:52,551,688–52,554,284 | 143.2 kb | Distal (>10kb) Multiome | 899 | |
| chr14:52,686,283–52,686,560 | 9.1 kb | Proximal (<10kb) | 20 | |
| chr14:52,694,713–52,696,105 | 151 bp | At TSS Multiome | 749 | |
| chr14:52,706,745–52,707,707 | 11.3 kb | Distal (>10kb) Multiome | 713 | |
| chr14:52,729,614–52,730,927 | 34.2 kb | Distal (>10kb) Multiome | 803 | |
| chr14:52,790,881–52,792,384 | 95.8 kb | Distal (>10kb) Multiome | 1077 | |
| chr14:52,827,263–52,828,172 | 131.7 kb | Distal (>10kb) Multiome | 103 | |
| chr14:52,835,079–52,835,883 | 139.5 kb | Distal (>10kb) Multiome | 369 | |
| chr14:52,852,332–52,854,201 | 157.4 kb | Distal (>10kb) Multiome | 475 | |
| chr14:52,950,305–52,952,252 | 255.3 kb | Distal (>10kb) Multiome | 746 |
Genomic view of the ERO1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.