Enables methyl-CpG binding activity. Predicted to be involved in pyrimidine nucleoside metabolic process. Located in midbody and nucleus. Part of methylosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ERH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:69,129,353–69,129,859 | 268.8 kb | Distal (>10kb) Multiome | 260 | |
| chr14:69,149,737–69,150,445 | 248.2 kb | Distal (>10kb) Multiome | 70 | |
| chr14:69,151,308–69,153,780 | 246.6 kb | Distal (>10kb) Multiome | 936 | |
| chr14:69,191,332–69,192,132 | 206.7 kb | Distal (>10kb) Multiome | 977 | |
| chr14:69,259,475–69,261,593 | 138.5 kb | Distal (>10kb) Multiome | 477 | |
| chr14:69,397,842–69,399,035 | 214 bp | At TSS Multiome | 926 | |
| chr14:69,483,950–69,485,210 | 86.3 kb | Distal (>10kb) Multiome | 334 | |
| chr14:69,547,663–69,548,492 | 149.8 kb | Distal (>10kb) Multiome | 213 | |
| chr14:69,561,722–69,562,330 | 163.8 kb | Distal (>10kb) Multiome | 67 | |
| chr14:69,571,579–69,572,640 | 173.9 kb | Distal (>10kb) Multiome | 300 | |
| chr14:69,574,502–69,574,973 | 176.4 kb | Distal (>10kb) Multiome | 302 | |
| chr14:69,611,065–69,612,800 | 213.3 kb | Distal (>10kb) Multiome | 628 |
Genomic view of the ERH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.