Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and positive regulation of intracellular protein transport. Located in membrane. Part of retrograde transporter complex, Golgi to ER. Biomarker of lung adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ERGIC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERGIC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERGIC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:35,262,839–35,263,582 | 278.8 kb | Distal (>10kb) Multiome | 336 | |
| chr20:35,269,197–35,269,766 | 272.6 kb | Distal (>10kb) Multiome | 447 | |
| chr20:35,277,415–35,278,519 | 264.0 kb | Distal (>10kb) Multiome | 575 | |
| chr20:35,284,235–35,285,360 | 257.3 kb | Distal (>10kb) Multiome | 950 | |
| chr20:35,303,859–35,304,479 | 238.0 kb | Distal (>10kb) Multiome | 484 | |
| chr20:35,454,521–35,455,845 | 86.9 kb | Distal (>10kb) Multiome | 1059 | |
| chr20:35,539,672–35,540,321 | 2.1 kb | Proximal (<10kb) Multiome | 311 | |
| chr20:35,541,280–35,542,685 | 10 bp | At TSS Multiome | 849 | |
| chr20:35,600,739–35,601,999 | 59.5 kb | Distal (>10kb) Multiome | 575 | |
| chr20:35,604,921–35,605,589 | 63.2 kb | Distal (>10kb) Multiome | 27 | |
| chr20:35,615,559–35,617,919 | 75.7 kb | Distal (>10kb) Multiome | 1169 | |
| chr20:35,618,589–35,619,849 | 77.4 kb | Distal (>10kb) Multiome | 865 | |
| chr20:35,664,428–35,665,171 | 122.8 kb | Distal (>10kb) Multiome | 1018 | |
| chr20:35,698,724–35,699,893 | 157.3 kb | Distal (>10kb) Multiome | 1035 | |
| chr20:35,741,564–35,742,903 | 200.3 kb | Distal (>10kb) Multiome | 1145 | |
| chr20:35,769,101–35,769,560 | 227.2 kb | Distal (>10kb) Multiome | 415 | |
| chr20:35,771,622–35,772,463 | 230.0 kb | Distal (>10kb) Multiome | 998 |
Genomic view of the ERGIC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.