ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]
Transcription factors with Perturb-seq knockdown data for ERGIC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERGIC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERGIC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:29,148,402–29,150,308 | 231.7 kb | Distal (>10kb) Multiome | 532 | |
| chr12:29,169,804–29,170,896 | 210.9 kb | Distal (>10kb) Multiome | 173 | |
| chr12:29,228,588–29,229,353 | 152.2 kb | Distal (>10kb) Multiome | 42 | |
| chr12:29,316,453–29,317,293 | 64.2 kb | Distal (>10kb) Multiome | 132 | |
| chr12:29,373,843–29,374,700 | 6.5 kb | Proximal (<10kb) | 128 | |
| chr12:29,380,457–29,381,649 | 17 bp | At TSS Multiome | 752 | |
| chr12:29,640,567–29,641,500 | 259.8 kb | Distal (>10kb) Multiome | 109 | |
| chr12:30,753,361–30,755,548 | 1373.8 kb | Distal (>10kb) Multiome HiCAR | 947 | |
| chr12:30,822,368–30,823,621 | 1441.6 kb | Distal (>10kb) Multiome HiCAR | 254 |
Genomic view of the ERGIC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.