The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for ERAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:96,661,819–96,663,768 | 145.8 kb | Distal (>10kb) Multiome | 856 | |
| chr5:96,702,491–96,703,472 | 105.1 kb | Distal (>10kb) Multiome | 828 | |
| chr5:96,806,184–96,806,743 | 1.2 kb | Proximal (<10kb) | 90 | |
| chr5:96,807,053–96,808,809 | 355 bp | At TSS Multiome | 1054 | |
| chr5:96,812,985–96,813,197 | 5.0 kb | Proximal (<10kb) | 31 | |
| chr5:96,816,334–96,816,762 | 8.4 kb | Proximal (<10kb) | 173 | |
| chr5:96,934,346–96,937,145 | 127.1 kb | Distal (>10kb) Multiome | 1171 | |
| chr5:97,142,252–97,143,299 | 334.8 kb | Distal (>10kb) Multiome HiCAR | 308 | |
| chr5:98,767,947–98,770,957 | 1960.3 kb | Distal (>10kb) Multiome HiCAR | 756 |
Genomic view of the ERAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.