Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EPRS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPRS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPRS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:219,834,079–219,834,880 | 212.0 kb | Distal (>10kb) Multiome | 136 | |
| chr1:219,839,143–219,840,267 | 206.7 kb | Distal (>10kb) Multiome | 246 | |
| chr1:220,045,998–220,046,836 | 11 bp | At TSS Multiome | 976 | |
| chr1:220,089,552–220,090,573 | 43.4 kb | Distal (>10kb) Multiome | 779 | |
| chr1:220,093,676–220,094,911 | 47.6 kb | Distal (>10kb) Multiome | 815 | |
| chr1:220,271,709–220,273,089 | 225.9 kb | Distal (>10kb) Multiome | 984 | |
| chr1:220,338,584–220,339,585 | 292.4 kb | Distal (>10kb) Multiome | 180 | |
| chr1:220,689,932–220,691,083 | 643.8 kb | Distal (>10kb) Multiome HiCAR | 763 |
Genomic view of the EPRS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.