This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for EPC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:30,783,902–30,784,662 | 1594.7 kb | Distal (>10kb) Multiome HiCAR | 300 | |
| chr10:30,784,858–30,785,789 | 1593.4 kb | Distal (>10kb) Multiome HiCAR | 462 | |
| chr10:32,055,513–32,056,824 | 322.4 kb | Distal (>10kb) Multiome | 887 | |
| chr10:32,150,441–32,151,508 | 227.8 kb | Distal (>10kb) Multiome | 259 | |
| chr10:32,265,752–32,266,479 | 112.8 kb | Distal (>10kb) Multiome | 182 | |
| chr10:32,266,857–32,267,419 | 111.6 kb | Distal (>10kb) Multiome | 101 | |
| chr10:32,345,913–32,347,750 | 32.4 kb | Distal (>10kb) Multiome | 1064 | |
| chr10:32,348,655–32,348,849 | 1.5 kb | Proximal (<10kb) | 35 | |
| chr10:32,352,732–32,353,142 | 5.5 kb | Proximal (<10kb) | 119 | |
| chr10:32,378,318–32,378,948 | 3 bp | At TSS Multiome | 583 | |
| chr10:32,379,388–32,379,855 | 913 bp | At TSS Multiome | 367 | |
| chr10:32,445,625–32,446,967 | 67.4 kb | Distal (>10kb) Multiome | 813 |
Genomic view of the EPC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.