Enables transcription coactivator activity. Involved in poly(A)+ mRNA export from nucleus; positive regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleoplasm. Part of SAGA complex and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ENY2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENY2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENY2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:109,138,815–109,140,452 | 194.8 kb | Distal (>10kb) Multiome | 174 | |
| chr8:109,189,362–109,190,475 | 144.6 kb | Distal (>10kb) Multiome | 169 | |
| chr8:109,262,011–109,263,133 | 71.9 kb | Distal (>10kb) Multiome | 324 | |
| chr8:109,281,877–109,282,698 | 52.1 kb | Distal (>10kb) Multiome | 264 | |
| chr8:109,325,948–109,326,310 | 8.0 kb | Proximal (<10kb) | 113 | |
| chr8:109,333,269–109,335,026 | 22 bp | At TSS Multiome | 1002 | |
| chr8:109,361,479–109,363,684 | 27.7 kb | Distal (>10kb) Multiome | 529 | |
| chr8:109,538,966–109,540,699 | 205.5 kb | Distal (>10kb) Multiome | 1183 |
Genomic view of the ENY2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.