ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for ENTPD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENTPD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENTPD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:24,992,035–24,993,195 | 202.9 kb | Distal (>10kb) Multiome HiCAR | 943 | |
| chr20:25,081,073–25,082,266 | 114.3 kb | Distal (>10kb) Multiome | 338 | |
| chr20:25,195,309–25,197,066 | 16 bp | At TSS Multiome | 970 | |
| chr20:25,247,007–25,249,001 | 52.4 kb | Distal (>10kb) Multiome | 1035 | |
| chr20:25,389,726–25,391,241 | 195.2 kb | Distal (>10kb) Multiome | 1021 | |
| chr20:25,407,111–25,408,013 | 212.0 kb | Distal (>10kb) Multiome | 1021 |
Genomic view of the ENTPD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.