The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ENTPD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENTPD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENTPD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,762,846–136,763,902 | 290.8 kb | Distal (>10kb) Multiome | 271 | |
| chr9:136,788,889–136,789,680 | 264.8 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr9:136,790,433–136,792,285 | 263.0 kb | Distal (>10kb) Multiome | 864 | |
| chr9:136,798,823–136,801,421 | 252.7 kb | Distal (>10kb) Multiome | 874 | |
| chr9:136,807,251–136,808,764 | 246.2 kb | Distal (>10kb) Multiome | 714 | |
| chr9:136,842,325–136,842,872 | 211.6 kb | Distal (>10kb) Multiome | 492 | |
| chr9:136,846,187–136,850,214 | 204.6 kb | Distal (>10kb) Multiome | 1074 | |
| chr9:136,865,842–136,866,772 | 187.7 kb | Distal (>10kb) Multiome | 742 | |
| chr9:136,885,976–136,887,547 | 167.7 kb | Distal (>10kb) Multiome | 770 | |
| chr9:136,943,250–136,945,621 | 109.4 kb | Distal (>10kb) Multiome | 883 | |
| chr9:136,949,631–136,950,846 | 103.9 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,977,106–136,980,430 | 75.5 kb | Distal (>10kb) Multiome | 413 | |
| chr9:136,991,827–136,993,248 | 61.7 kb | Distal (>10kb) Multiome | 720 | |
| chr9:137,027,536–137,029,054 | 25.8 kb | Distal (>10kb) Multiome | 539 | |
| chr9:137,029,231–137,029,652 | 24.5 kb | Distal (>10kb) Multiome | 386 | |
| chr9:137,045,334–137,046,838 | 7.5 kb | Proximal (<10kb) Multiome | 829 | |
| chr9:137,048,790–137,049,143 | 4.9 kb | Proximal (<10kb) | 125 | |
| chr9:137,053,352–137,054,892 | 84 bp | At TSS Multiome | 544 | |
| chr9:137,067,810–137,068,494 | 14.1 kb | Distal (>10kb) Multiome HiCAR | 492 | |
| chr9:137,069,879–137,071,138 | 16.6 kb | Distal (>10kb) Multiome | 703 | |
| chr9:137,076,758–137,078,723 | 23.4 kb | Distal (>10kb) Multiome | 530 | |
| chr9:137,085,844–137,087,716 | 32.8 kb | Distal (>10kb) Multiome | 890 | |
| chr9:137,129,244–137,130,499 | 75.8 kb | Distal (>10kb) Multiome | 823 | |
| chr9:137,167,984–137,170,155 | 115.4 kb | Distal (>10kb) Multiome | 560 | |
| chr9:137,188,099–137,189,538 | 134.7 kb | Distal (>10kb) Multiome | 954 | |
| chr9:137,200,175–137,201,689 | 146.8 kb | Distal (>10kb) Multiome | 856 | |
| chr9:137,205,371–137,205,975 | 151.6 kb | Distal (>10kb) Multiome | 758 | |
| chr9:137,221,373–137,224,294 | 167.9 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,227,249–137,228,051 | 173.6 kb | Distal (>10kb) Multiome | 533 | |
| chr9:137,236,161–137,237,143 | 182.6 kb | Distal (>10kb) Multiome | 748 | |
| chr9:137,239,991–137,242,933 | 187.0 kb | Distal (>10kb) Multiome | 1117 | |
| chr9:137,243,659–137,245,307 | 190.2 kb | Distal (>10kb) Multiome | 471 | |
| chr9:137,253,801–137,256,036 | 201.2 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,280,593–137,281,861 | 227.1 kb | Distal (>10kb) Multiome | 223 | |
| chr9:137,294,859–137,296,916 | 241.5 kb | Distal (>10kb) Multiome | 501 | |
| chr9:137,300,591–137,303,141 | 248.4 kb | Distal (>10kb) Multiome | 790 | |
| chr9:137,316,104–137,316,916 | 262.2 kb | Distal (>10kb) Multiome | 395 |
Genomic view of the ENTPD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.