Transcription factors with Perturb-seq knockdown data for ENSG00000293253. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000293253 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000293253, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:53,430,779–53,431,233 | 8.7 kb | Proximal (<10kb) | 103 | |
| chr1:53,434,593–53,435,793 | 4.2 kb | Proximal (<10kb) | 122 | |
| chr1:53,442,378–53,442,615 | 2.4 kb | Proximal (<10kb) | 51 | |
| chr1:53,444,649–53,444,867 | 4.7 kb | Proximal (<10kb) | 21 | |
| chr1:53,449,173–53,450,171 | 9.2 kb | Proximal (<10kb) | 106 |
Genomic view of the ENSG00000293253 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.